Search results for "blood circulation"
showing 10 items of 27 documents
Alkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Ves…
2013
The blood-brain barrier prevents the passage of toxic compounds from blood circulation into brain tissue. Unfortunately, drugs for the treatment of neurodegenerative diseases, brain tumors, and other diseases also do not cross the blood-brain barrier. In the present investigation, we used isolated porcine brain capillary endothelial cells and a flow cytometric calcein-AM assay to analyze inhibition of P-glycoprotein, a major constituent of the blood-brain barrier. We tested 8 alkamides isolated from Echinacea angustifolia and found that four of them inhibited P-glycoprotein-mediated calcein transport in porcine brain capillary endothelial cells.
The road to gold: Training and peaking characteristics in the year prior to a gold medal endurance performance
2014
Published version of an article in the journal PLoS ONE. Also available from the publisher at: http://dx.doi.org/10.1371/journal.pone.0101796 Open Access Purpose: To describe training variations across the annual cycle in Olympic and World Champion endurance athletes, and determine whether these athletes used tapering strategies in line with recommendations in the literature. Methods: Eleven elite XC skiers and biathletes (4 male; 28±1 yr, 85±5 mL. min-1. kg-1 V̇O2max, 7 female, 25±4 yr, 73±3 mL. min-1. kg-1 V̇O2max) reported one year of day-to-day training leading up to the most successful competition of their career. Training data were divided into periodization and peaking phases and dis…
Evaluation of breast tumor blood flow with dynamic first-pass 18F-FDG PET/CT: comparison with angiogenesis markers and prognostic factors
2012
The purpose of this study was to prospectively evaluate the relationship between tumor blood flow and glucose metabolism as evaluated by dynamic first-pass (18)F-FDG PET and by proliferation and endothelial pathologic markers in the setting of newly diagnosed breast cancer.Forty patients were prospectively included. Biopsy samples of each tumor were used to assess the Ki67 index of proliferation and immunostaining for CD34 (a panendothelial cell marker) and CD105 (a proliferation-related endothelial cell marker). All patients underwent (18)F-FDG PET/CT at least 1 wk after sample biopsy and before any treatment. A dynamic 2-min acquisition was performed immediately after intravenous injectio…
Effects of a low-frequency sound wave therapy programme on functional capacity, blood circulation and bone metabolism in frail old men and women
2009
Objective: To evaluate the effects of a low-frequency sound wave therapy programme on functional capacity, blood circulation and bone metabolism of the frail elderly. Design: Single-blind, randomized, controlled trial. Setting: Two senior service centres. Subjects: Forty-nine volunteers (14 males and 35 females) aged 62—93 years with up to 12 diagnosed diseases were allocated in either the intervention group (n = 30) or control group (n = 19). Intervention: The intervention group underwent sound wave therapy, 3—5 times a week for 30 minutes per session over a period of 6 months. The control group received no intervention. Main measurements: Blood pressure, functional capacity, mobility, bo…
Anti-Hypotensive Treatment and Endothelin Blockade Synergistically Antagonize Exercise Fatigue in Rats under Simulated High Altitude
2013
Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an endothelin receptor A antagonist drugs would limit exercise-induced fatigue at simulated high altitude. Our data showed that the combination of 0.1 mg/kg ambrisentan with either 20 mg/kg ephedrine or 10 mg/kg methylphenidate significantly improved exercise duration in rats at simulated altitude of 4,267 m, whereas the individual compounds did not. In normoxic, anesthetized rats, ephedrine alone and in combination with ambrisentan increased heart…
Photoplethysmography for bovine heat detection: the preliminary results
2020
In this study, we applied photoplethysmography (PPG) as an alternative, convenient, and affordable method for bovine heat detection. Heat detection is an essential part of effective herd reproduction management. Currently, there are many different heat detection techniques, but they can be ineffective or impractical to use. Since heat affects local vulvar blood circulation (resulting in swelling and erythema), photoplethysmography could represent an affordable alternative to detect this bovine phenomenon. In this study, we enrolled 20 animals in heat and other stages of the bovine reproduction cycle. We analyzed the PPG signal in terms of baseline (DC component), power, kurtosis, and erythe…
Durchblutung und Sauerstoffverbrauch gewebsisolierter Impftumoren (DS-Carcinosarkom) in vivo
1971
Nach einer von Gullino u. Grantham (1961) angegebenen Methode wurden DS-Carcino-Sarkomzellen in Rattennieren verimpft und gewebsisoliert gezuchtet. Nach im Mittel 11 Tagen hat der infiltrierend und destruierend wachsende Tumor das Nierengewebe meist vollig ersetzt und steht mit dem Wirtstier nur uber eine Arterie und eine Vene in Verbindung. Die Tumordurchblutungsmessungen erfolgten nach Kanulierung der Tumorvene druckkonstant mit Hilfe eines Rollenpumpen-Windkessel-Systems uber eine Mescapillare. Gleichzeitig konnten Mikroblutproben unter Luftabschlus aus Tumorvene und Aorta entnommen und pH, O2-Druck, CO2-Druck, Hb-Konzentration und Hamatokrit bestimmt werden. Aus der errechneten arterio-…
Kreislaufuntersuchungen �ber Eledoisin mit Therapieresultaten
1965
Nachdem die Wirkung von synthetischem Eledoisin auf die Summengrosen des grosen und kleinen Kreislaufs des Menschen, auf die Haut- und Muskeldurchblutung von Gesunden und Gefaskranken sowie auf die Carotis communis — wie Carotis interna-Schlingen von Hunden untersucht worden war, wurden Kranke mit peripheren arteriellen Verschlusleiden, zum Teil uber viele Wochen, mit Eledoisin behandelt. Entgegen der herrschenden Auffassung wurden die klinisch-pharmakologischen Untersuchungen uberwiegend und die therapeutische Anwendung ausschlieslich mit intravenoser Applikation ausgefuhrt.
Harvey's doctrine of the circulation of the blood in seventeenth-century Spain.
1973
Effects of the exercise in the cerebral blood flow and metabolism: A review
2015
In recent years it has been shown that cerebral blood flow is affected by intense exercise, what may even lead to a reduction in the cognitive capacity. This statement is contrary to the traditional belief that cerebral blood flood remains constant and unaltered even when exercise is performed. During physical exercise of moderate intensity, cerebral blood flow increases in the cerebral areas responsible for movement. Moreover, recent studies have observed that cerebral blood flow decreases during high-intensity exercise as a consequence of a local hyperventilation and vasoconstriction of the areas with lower cerebral activity. Traditionally, the glucose has been considered as the main and …